Recombinant Human Annexin A5
نویسندگان
چکیده
منابع مشابه
Annexin A5 stimulates autophagy and inhibits endocytosis.
Macroautophagy is a major lysosomal catabolic process activated particularly under starvation in eukaryotic cells. A new organelle, the autophagosome, engulfs cytoplasmic substrates, which are degraded after fusion with endosomes and/or lysosomes. During a shotgun proteome analysis of purified lysosomal membranes from mouse fibroblasts, a Ca(2+)-dependent phospholipid-binding protein, annexin A...
متن کاملRecombinant human annexin A5 inhibits proinflammatory response and improves cardiac function and survival in mice with endotoxemia.
OBJECTIVES Annexin A5 is a 35-kDa protein with high affinity binding to negatively charged phospholipids. However, its effects on sepsis are not known. Our aim was to study the effects of annexin A5 on myocardial tumor necrosis factor-α expression, cardiac function, and animal survival in endotoxemia. DESIGN Prospective experimental study. SETTING University laboratory. SUBJECTS Adult mal...
متن کاملAnti-annexin A5 antibodies in women with spontaneous pregnancy loss.
BACKGROUND AND OBJECTIVE The aim was to evaluate the role of anti-annexin A5 (anti-ANXA5) antibodies as risk factor for recurrent miscarriage (RM) and unexplained fetal loss (UFL). PATIENTS AND METHODS Retrospective, cohort study. SETTING Vall d'Hebron University Hospital. SUBJECTS 122 women, in two groups: STUDY GROUP 54 women with RM/UFL and control group: 68 pregnant without RM/UFL. ...
متن کاملInternalization of Annexin A5-USPIOs by Apoptotic Cells
G. A. van Tilborg, G. J. Strijkers, H. Duimel, P. Bomans, P. M. Frederik, C. P. Reutelingsperger, K. Nicolay Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, EM unit, Department of Pathology, University of Maastricht, Maastricht, Netherlands, Cardiovascular Research Institute of Maastricht, Department of Biochemistry, Maastricht U...
متن کاملAnnexin A5 Binds to Lipopolysaccharide and Reduces Its Endotoxin Activity
UNLABELLED Annexin A5 (AnxA5) has a high affinity for phosphatidylserine. The protein is widely used to detect apoptotic cells because phosphatidylserine, a phospholipid that is normally present in the inner leaflets of cytoplasmic membranes, becomes translocated to the outer leaflets during programmed cell death. Here we report the novel observation that AnxA5 binds to Gram-negative bacteria v...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2014
ISSN: 0090-3493
DOI: 10.1097/01.ccm.0000435680.21801.0f